I have found from my experience is that you need a list of buyers. You should have your e-mail segmented from those who buy your products and offers and those who just are on your list for free information. The free information seekers are a waste of your time.
Now, at the same time, you should not only communicate with your list to sell things and make offers. You should be adding valuable, relevant information that they can use. If they believe that everytime you mail them its to buy something, they'll quickly begin to ignore your e-mails and unsubscribe.
Also, make your subject line stick out: (**you won't believe how bad this is**)
Bad news headlines work, the "(**" grabs the attention of your reader and gets them to focus on your subject line when they scan their inbox.
Another good time, repeat that link at least three times in the e-mail and ALWAYS have a "P.S." that is your call to your action. Many people simply scroll to the bottom of your e-mail to get to the point.
You should have your autoresponder automated. if you're using Aweber
this is easy. Grab private label right articles or ezine articles if you don't want to write. Spend 2 hours at the start of the month pulling together these articles and scheduling them to be sent to your list.
Content is king, and always will be. Once you provide value to your list, they will respect you as an authority and friend. Then when you recommend products they will buy from you. Just like in the real world.